| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38520382 | High-dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT |
| Curcumin | 📋 | ✍ | ⛔ | | 38707049 | Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study |
| Melatonin | 📋 | ✍ | ⛔ | | 38540297 | Melatonin Decreases Alveolar Bone Loss in Rats with Experimental Periodontitis and Osteoporosis: A Morphometric and Histopathologic Study |
| Resveratrol | 📋 | ✍ | ⛔ | | 38706943 | Resveratrol facilitates bone formation in high-glucose conditions |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38650149 | Ginsenoside Rc alleviates osteoporosis by the TGF-β/Smad signaling pathway |
| Quercetin | 📋 | ✍ | ⛔ | | 38652430 | Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential |
| Berberine | 📋 | ✍ | ⛔ | | 38723878 | Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis |
| Vitamin C | 📋 | ✍ | ⛔ | | 38599880 | Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance |
| Metformin | 📋 | ✍ | ⛔ | | 38536446 | Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study |
| EGCG | 📋 | ✍ | ⛔ | | 38259454 | J-shaped association of dietary catechins intake with the prevalence of osteoarthritis and moderating effect of physical activity: an American population-based cohort study |
| Icariin | 📋 | ✍ | | | 38680705 | Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus |
| Genistein | 📋 | ✍ | ⛔ | | 38030209 | Genistein Induces Antiproliferative Activity and Apoptosis in Human Osteosarcoma Saos-2 Cells |
| Puerarin | 📋 | ✍ | ⛔ | | 38554122 | FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption |
| Naringin | 📋 | ✍ | ⛔ | | 38312545 | Study on the mechanism of naringin in promoting bone differentiation: In vitro and in vivo study |
| Glucosamine | 📋 | ✍ | ⛔ | | 38732122 | Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38248642 | The Role of Marine n-3 Polyunsaturated Fatty Acids in Inflammatory-Based Disease: The Case of Rheumatoid Arthritis |
| Frankincense | 📋 | ✍ | ⛔ | | 38707049 | Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study |
| Chondroitin | 📋 | ✍ | ⛔ | | 38707049 | Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study |
| Medicinal Plants | 📋 | | | | 38676473 | Nature's Pharmacy: Herbal Interventions in Rheumatoid Arthritis Treatment: A Comprehensive Review |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 36998133 | VK2 promotes osteogenic differentiation of BMSCs against high glucose exposure via modulation of intracellular oxidative stress |
| Cannabidiol | 📋 | ✍ | ⛔ | | 37597163 | Cannabidiol and cannabigerol, non-psychotropic cannabinoids, as analgesics that effectively manage bone fracture pain and promote healing in mice |
| Magnesium | 📋 | ✍ | ⛔ | | 38178208 | Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis |
| Plum | 📋 | | ⛔ | | 38375074 | Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38623993 | Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 37364692 | Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37571336 | Effects of Menaquinone-7 on the Bone Health of Growing Rats under Calcium Restriction: New Insights from Microbiome-Metabolomics |
| Hesperidin | 📋 | ✍ | ⛔ | | 38297106 | Mitigation of BMP-induced inflammation in craniofacial bone regeneration and improvement of bone parameters by dietary hesperidin |
| Vitamin K | 📋 | ✍ | ⛔ | | 38068793 | The Potential of Vitamin K as a Regulatory Factor of Bone Metabolism-A Review |
| Zinc | 📋 | ✍ | ⛔ | | 38003398 | Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection |
| Ginseng | 📋 | ✍ | ⛔ | | 38533264 | Korean red ginseng extract prevents bone loss in an oral model of glucocorticoid induced osteoporosis in mice |
| Astragalosides | 📋 | ✍ | ⛔ | | 38461631 | Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway |
| Calcium | 📋 | ✍ | ⛔ | | 38433741 | Association of Calcium and Vitamin D Supplements with Fractures in Persons with a Traumatic SCI |
| Collagen | 📋 | ✍ | | | 38180010 | Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction |
| Kaempferol | 📋 | ✍ | ⛔ | | 38528143 | Network pharmacology analysis and experimental validation to explore the mechanism of kaempferol in the treatment of osteoporosis |
| Salidroside | 📋 | | | | 38724500 | Salidroside promotes the repair of spinal cord injury by inhibiting astrocyte polarization, promoting neural stem cell proliferation and neuronal differentiation |
| Andrographolide | 📋 | | | | 38462021 | Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation |
| Selenium | 📋 | ✍ | ⛔ | | 38473759 | Selenium Lessens Osteoarthritis by Protecting Articular Chondrocytes from Oxidative Damage through Nrf2 and NF-κB Pathways |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 38707049 | Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study |
| Naringenin | 📋 | ✍ | ⛔ | | 37953787 | Naringenin attenuates inflammation and apoptosis of osteoarthritic chondrocytes via the TLR4/TRAF6/NF-κB pathway |
| Micronutrients | 📋 | | ⛔ | | 38650834 | Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence |
| Baicalin | 📋 | ✍ | ⛔ | | 38677248 | Restoring bone-fat equilibrium: Baicalin's impact on P38 MAPK pathway for treating diabetic osteoporosis |
| Food | 📋 | | | | 38665424 | The effects of popular diets on bone health in the past decade: a narrative review |
| Tanshinone | 📋 | | | | 38552937 | Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain |
| Turmeric | 📋 | ✍ | ⛔ | | 38180010 | Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction |
| Vitamin E | 📋 | ✍ | ⛔ | | 36986484 | The Role of Tocotrienol in Arthritis Management-A Scoping Review of Literature |
| Apigenin | 📋 | ✍ | ⛔ | | 38638133 | Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells |
| Eucommia | 📋 | ✍ | ⛔ | | 37396732 | Effect of Eucommia Ulmoides on Healing of Bon Defect Using Histological and Histomorphometric Analysis in Rat: in vivo Study |
| Fisetin | 📋 | ✍ | ⛔ | | 38428149 | Fisetin orchestrates neuroinflammation resolution and facilitates spinal cord injury recovery through enhanced autophagy in pro-inflammatory glial cells |
| Ginger | 📋 | ✍ | ⛔ | | 38474869 | Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice-Preclinical and Clinical Evidence |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38647358 | The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis |
| Luteolin | 📋 | ✍ | ⛔ | | 38547625 | Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling |
| Lycopene | 📋 | ✍ | ⛔ | | 37880898 | Lycopene Improves Bone Quality in SAMP6 Mice by Inhibiting Oxidative Stress, Cellular Senescence, and the SASP |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38318502 | Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis |
| Beta-Cryptoxanthin | 📋 | | | | 37378145 | Diet as a Risk Factor for Rheumatoid Arthritis |
| Formononetin | 📋 | | | | 37870753 | Anti-cancer targets and molecular mechanisms of formononetin in treating osteosarcoma based on network pharmacology |
| Mangiferin | 📋 | | ⛔ | | 38176266 | Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 38650731 | The efficacy and safety of Nigella sativa in the management of osteoarthritis: A systematic review |
| Oleuropein | 📋 | | | | 37543863 | Oleuropein as An Effective Suppressor of Inflammation and MicroRNA-146a Expression in Patients with Rheumatoid Arthritis |
| Angelica | 📋 | ✍ | ⛔ | | 37632225 | Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways |
| CoQ10 | 📋 | ✍ | ⛔ | | 38685349 | Neuroprotective Effects Of Coenzyme Q 10 And Ozone Therapy On Experimental Traumatic Spinal Cord Injuries In Rats |
| Fish Oil | 📋 | ✍ | ⛔ | | 35099432 | Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis |
| Fucoidan | 📋 | ✍ | ⛔ | | 37308428 | [Effects of fucoidan inducing impairment of human osteosarcoma cell 143B and its mechanism] |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 37219787 | Marantodes pumilum (Kacip Fatimah) Aqueous Extract Enhances Osteoblast and Suppresses Osteoclast Activities in Cancellous Bone of a Rat Model of Postmenopause |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37975960 | The Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury |
| Phytochemicals | 📋 | | | | 38535306 | Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging |
| Red Sage | 📋 | ✍ | ⛔ | | 38213257 | Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 37311556 | The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review |
| MSM | 📋 | ✍ | ⛔ | | 37447322 | Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial |
| Senolytics | 📋 | | | | 38535306 | Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging |
| Tea | 📋 | | | | 38672942 | Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study |
| TUDCA | 📋 | ✍ | ⛔ | | 38665027 | Tauroursodeoxycholic Acid Mitigates Oxidative Stress and Promotes Differentiation in High Salt-Stimulated Osteoblasts via NOX1 Mediated by PGC-1α |
| Allicin | 📋 | ✍ | ⛔ | | 34026055 | Allicin regulates Treg/Th17 balance in mice with collagen-induced arthritis by increasing the expression of MEKK2 protein |
| Avocado | 📋 | ✍ | ⛔ | | 37936023 | Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI-MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model |
| Baicalein | 📋 | ✍ | ⛔ | | 38525128 | Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 36869332 | Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial |
| Emodin | 📋 | | ⛔ | | 38570055 | Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 38037139 | Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis |
| Pine Bark | 📋 | ✍ | ⛔ | | 38381030 | Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum® |
| Asiatic Acid | 📋 | | | | 38567545 | Asiatic acid inhibits osteosarcoma cell migration and invasion via the AKT/Sp1/MMP1 axis |
| Crocin | 📋 | ✍ | ⛔ | | 37031388 | The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38472087 | Alleviating Severe Cytoskeletal Destruction of Spinal Motor Neurons: Another Effect of Docosahexaenoic Acid in Spinal Cord Injury |
| Geniposide | 📋 | | | | 38468352 | Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway |
| Polyphenols | 📋 | | | | 37936705 | The synergistic effects of polyphenols and intestinal microbiota on osteoporosis |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 37586160 | Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways |
| Rutin | 📋 | ✍ | ⛔ | | 38374412 | Anticancer effects of rutin from Fagopyrum tataricum (tartary buckwheat) against osteosarcoma cell line |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 36169025 | Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk: the Perth longitudinal study of ageing women |
| Bee Propolis | 📋 | ✍ | ⛔ | | 37834215 | Ethanolic Extract of Propolis Modulates Autophagy-Related microRNAs in Osteoarthritic Chondrocytes |
| Chrysin | 📋 | ✍ | ⛔ | | 37111711 | Chrysin Is Immunomodulatory and Anti-Inflammatory against Complete Freund's Adjuvant-Induced Arthritis in a Pre-Clinical Rodent Model |
| Cinnamon | 📋 | ✍ | ⛔ | | 36160710 | Integrated Experimental Approach, Phytochemistry, and Network Pharmacology to Explore the Potential Mechanisms of Cinnamomi Ramulus for Rheumatoid Arthritis |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 36547073 | Regulatory Effects and Mechanism of Action of Green Tea Polyphenols on Osteogenesis and Adipogenesis in Human Adipose Tissue-Derived Stem Cells |
| Hesperetin | 📋 | | | | 38556120 | Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response |
| Irisin | 📋 | | | | 38672282 | Irisin and Its Role in Postmenopausal Osteoporosis and Sarcopenia |
| Mangosteen | 📋 | ✍ | ⛔ | | 36634312 | Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo |
| Peony | 📋 | | ⛔ | | 38649260 | Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis |
| Punicalagin | 📋 | ✍ | ⛔ | | 37429372 | Punicalagin attenuates TNF-α-induced oxidative damage and promotes osteogenic differentiation of bone mesenchymal stem cells by activating the Nrf2/HO-1 pathway |
| Soy | 📋 | ✍ | ⛔ | | 35733624 | A Randomized Controlled Trial of Thai Medicinal Plant-4 Cream versus Diclofenac Gel in the Management of Symptomatic Osteoarthritis of the Knee |
| Sulforaphane | 📋 | ✍ | ⛔ | | 36647429 | Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1 |
| Wogonin | 📋 | ✍ | ⛔ | | 38552763 | Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis |
| Boron | 📋 | ✍ | ⛔ | | 34082267 | Borate and boric acid supplementation of drinking water alters teeth and bone mineral density and composition differently in rabbits fed a high protein and energy diet |
| Bromelain | 📋 | ✍ | ⛔ | | 35881306 | Combination of Enzymes and Rutin to Manage Osteoarthritis Symptoms: Lessons from a Narrative Review of the Literature |
| Calycosin | 📋 | | | | 38254101 | Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism |
| Cinnamaldehyde | 📋 | | | | 38628640 | Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction |
| Coffee | 📋 | ✍ | ⛔ | | 38672942 | Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study |
| Ginkgolides | 📋 | | | | 38346525 | Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis |
| Goji Berry | 📋 | ✍ | ⛔ | | 37439115 | Tissue lipidomics, network pharmacology, and molecular docking to explore the therapeutic mechanism of anthocyanins from Lycium ruthenicum Murr. against gouty arthritis |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 30914844 | An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models |
| Bee Venom | 📋 | ✍ | ⛔ | | 38414737 | Melittin promotes dexamethasone in the treatment of adjuvant rheumatoid arthritis in rats |
| Cherry | 📋 | | ⛔ | | 37679816 | Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study |
| DHEA | 📋 | ✍ | ⛔ | | 34935937 | Endogenous DHEAS is Causally Linked with Lumbar Spine Bone Mineral Density and Forearm Fractures in Women |
| Dihydroquercetin | 📋 | | | | 37846877 | Taxifolin-mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid-induced osteonecrosis of the femoral head |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38145796 | Ellagic acid promotes osteoblasts differentiation via activating SMAD2/3 pathway and alleviates bone mass loss in OVX mice |
| Flavonoids | 📋 | | ⛔ | | 38201942 | Osteoarthritis in the Elderly Population: Preclinical Evidence of Nutrigenomic Activities of Flavonoids |
| Galangin | 📋 | | | | 37365870 | Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway |
| Paeoniflorin | 📋 | | | | 38726183 | Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012 |
| Polydatin | 📋 | ✍ | | | 38606875 | Polydatin protects against articular cartilage degeneration by regulating autophagy mediated by the AMPK/mTOR signaling pathway |
| Pomegranate | 📋 | | ⛔ | | 35079584 | Systematic review of the effects of pomegranate ( Punica granatum) on osteoarthritis |
| PQQ | 📋 | ✍ | ⛔ | | 37365714 | Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation |
| Probiotics | 📋 | ✍ | ⛔ | | 36217542 | Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials |
| Thymoquinone | 📋 | | ⛔ | | 37893499 | Effects of Thymoquinone on Urotensin-II and TGF-β1 Levels in Model of Osteonecrosis in Rats |
| Ashwagandha | 📋 | ✍ | ⛔ | | 34712426 | Anti-arthritic activity of Ricinus communis L. and Withania somnifera L. extracts in adjuvant-induced arthritic rats via modulating inflammatory mediators and subsiding oxidative stress |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 38019728 | Diet-derived antioxidants and osteoporosis: A Mendelian randomization study |
| Catalpol | 📋 | | | | 38100921 | Catalpol attenuates osteoporosis in ovariectomized rats through promoting osteoclast apoptosis via the Sirt6-ERα-FasL axis |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 34265701 | Dihydromyricetin suppresses cell metastasis in human osteosarcoma through SP-1- and NF-κB-modulated urokinase plasminogen activator inhibition |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38138300 | Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial |
| Arctigenin | 📋 | | | | 37711016 | Arctigenin Suppresses the Proliferation and Metastasis, and Induces Apoptosis and Cycle Arrest of Osteosarcoma Cells by inhibiting HMOX1 Expression |
| Gallic Acid | 📋 | | ⛔ | | 37939829 | Gallic acid exerts protective effects in spinal cord injured rats through modulating microglial polarization |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 35724747 | Ginkgo biloba L. extract prevents steroid-induced necrosis of the femoral head by rescuing apoptosis and dysfunction in vascular endothelial cells via the PI3K/AKT/eNOS pathway |
| Krill Oil | 📋 | ✍ | ⛔ | | 37888448 | Anti-Osteoarthritic Effects of Antarctic Krill Oil in Primary Chondrocytes and a Surgical Rat Model of Knee Osteoarthritis |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38389158 | Effect of l-Carnitine Supplementation on Osteoarthritis: A Systematic Review |
| Licochalcones | 📋 | | | | 35744886 | Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells |
| Licorice Root | 📋 | ✍ | ⛔ | | 38092318 | Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice |
| NMN | 📋 | ✍ | ⛔ | | 38155866 | The identification of new roles for nicotinamide mononucleotide after spinal cord injury in mice: an RNA-seq and global gene expression study |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38624135 | Pterostilbene Protects against Osteoarthritis through NLRP3 Inflammasome Inactivation and Improves Gut Microbiota as Evidenced by In Vivo and In Vitro Studies |
| Theaflavins | 📋 | ✍ | | | 36990009 | Mechanisms of theaflavins against gout and strategies for improving the bioavailability |
| Urolithins | 📋 | | | | 38465899 | Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation |
| Acacetin | 📋 | | | | 36590896 | Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury |
| Andrographis | 📋 | ✍ | ⛔ | | 37354697 | Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment |
| Blueberry | 📋 | ✍ | ⛔ | | 37269909 | Moderate Consumption of Freeze-dried Blueberry Powder Increased Net Bone Calcium Retention Compared with No Treatment in Healthy Postmenopausal Women: A Randomized Crossover Trial1,2 |
| Carnosic Acid | 📋 | | | | 36296709 | Combination Therapy of Carnosic Acid and Methotrexate Effectively Suppressed the Inflammatory Markers and Oxidative Stress in Experimental Arthritis |
| Daidzein | 📋 | ✍ | ⛔ | | 38474779 | Effect of Tempeh and Daidzein on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in Ovariectomized Rats |
| Dairy | 📋 | | | | 37950985 | Higher lacto-vegetarian dietary score is associated with reduced risk of postmenopausal osteoporosis: A case-control study in a sample of Iranian postmenopausal women |
| Green Tea | 📋 | ✍ | ⛔ | | 35513482 | Non-fermented tea consumption protects against osteoporosis among Chinese male elders using the Taiwan biobank database |
| L-Arginine | 📋 | ✍ | ⛔ | | 37775153 | L-arginine metabolism inhibits arthritis and inflammatory bone loss |
| Nobiletin | 📋 | ✍ | | | 36816515 | Nobiletin, a NF-κB signaling antagonist, promotes BMP-induced bone formation |
| Piperine | 📋 | ✍ | ⛔ | | 37536000 | Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 32794641 | Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL-2, MMP-3, and COX-2 expression |
| Procyanidins | 📋 | | ⛔ | | 38420419 | Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear |
| Schisandra | 📋 | ✍ | ⛔ | | 37337779 | Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways |
| Sesamin | 📋 | ✍ | | | 38284902 | Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38506303 | Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways |
| Amygdalin | 📋 | ✍ | ⛔ | | 37894605 | TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades |
| Asiaticoside | 📋 | | | | 37653222 | Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury |
| Cardamonin | 📋 | | | | 38520666 | Cardamonin inhibits osteogenic differentiation by downregulating Wnt/beta-catenin signaling and alleviates subchondral osteosclerosis in osteoarthritic mice |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 38144783 | Identification of key phenolic compounds for alleviating gouty inflammation in edible chrysanthemums based on spectrum-effect relationship analyses |
| Diosmin | 📋 | ✍ | ⛔ | | 36889109 | Diosmin mitigates dexamethasone-induced osteoporosis in vivo: Role of Runx2, RANKL/OPG, and oxidative stress |
| Echinacoside | 📋 | | | | 38506417 | Anti-inflammatory effect of echinacoside in collagen-induced arthritis via Nrf2/Drp1 pathway |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38339087 | Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte |
| Fish Collagen | 📋 | ✍ | ⛔ | | 38132929 | Low-Molecular-Weight Fish Collagen Peptide (Valine-Glycine-Proline-Hydroxyproline-Glycine-Proline-Alanine-Glycine) Prevents Osteoarthritis Symptoms in Chondrocytes and Monoiodoacetate-Injected Rats |
| Garlic | 📋 | ✍ | ⛔ | | 36945935 | Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures |
| Hydroxytyrosol | 📋 | | | | 36982904 | NOTCH1: A Novel Player in the Molecular Crosstalk Underlying Articular Chondrocyte Protection by Oleuropein and Hydroxytyrosol |
| Indian Gooseberry | 📋 | | ⛔ | | 35449811 | Exploring the Mechanism through which Phyllanthus emblica L. Extract Exerts Protective Effects against Acute Gouty Arthritis: A Network Pharmacology Study and Experimental Validation |
| Kudzu Root | 📋 | ✍ | ⛔ | | 38312605 | A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways |
| Ligustilide | 📋 | | | | 33545202 | Ligustilide inhibits the proliferation of human osteoblastoma MG63 cells through the TLR4-ERK pathway |
| Milk | 📋 | | ⛔ | | 38325238 | Effect of Calcium and Vitamin D Supplementation (Dairy vs. Pharmacological) on Bone Health of Underprivileged Indian Children and Youth with Type-1 Diabetes: A Randomized Controlled Trial |
| Neohesperidin | 📋 | | | | 35625554 | Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health |
| Nimbolide | 📋 | | | | 37250166 | Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling |
| Olive Oil | 📋 | ✍ | ⛔ | | 36839323 | Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 35003721 | Potential benefit of olive leaf extract in cervical spondylotic myelopathy model |
| Silibinin | 📋 | ✍ | | | 38732122 | Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 38191316 | Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway |
| Spirulina | 📋 | ✍ | ⛔ | | 35493310 | Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38570065 | Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain |
| Withaferin A | 📋 | | | | 38345447 | Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2 |
| Aloin | 📋 | | | | 35035490 | Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- κ B/NLRP3 Signaling Pathway |
| Artemisinin | 📋 | | | | 37758057 | Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin |
| Aspirin | 📋 | | ⛔ | | 37605888 | Berberine and aspirin prevent traumatic heterotopic ossification by inhibition of BMP signalling pathway and osteogenic differentiation |
| Boric Acid | 📋 | ✍ | ⛔ | | 38108177 | Investigation of the efficacy of epidermal growth factor, boric acid and their combination in cartilage injury in rats: An experimental study |
| CAPE | 📋 | | | | 37751634 | Caffeic acid phenethyl ester ameliorates titanium particle-induced bone loss and inflammatory reaction in a mouse acute model |
| Carvacrol | 📋 | ✍ | ⛔ | | 36983900 | Attenuation of Endoplasmic Reticulum Stress Enhances Carvacrol-Induced Apoptosis in Osteosarcoma Cell Lines |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38461437 | Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation |
| Copper | 📋 | ✍ | ⛔ | | 38003398 | Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection |
| Dihydroartemisinin | 📋 | | | | 38447418 | Dihydroartemisinin alleviates erosive bone destruction by modifying local Treg cells in inflamed joints: A novel role in the treatment of rheumatoid arthritis |
| Escin | 📋 | ✍ | ⛔ | | 30967782 | Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis |
| Essential Oils | 📋 | | ⛔ | | 36990808 | The Effects of Self-Aromatherapy Massage on Pain and Sleep Quality in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial |
| Eugenol | 📋 | | | | 37896013 | Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 36601662 | Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4/NF-κB pathway |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 31328115 | Heshouwu ( Polygonum multiflorum Thunb.) Extract Attenuates Bone Loss in Diabetic Mice |
| Folate | 📋 | ✍ | ⛔ | | 37710267 | Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study |
| Galangal | 📋 | ✍ | ⛔ | | 33818795 | Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants |
| Gotu Kola | 📋 | ✍ | ⛔ | | 38381030 | Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum® |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 38403321 | [UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss] |
| Phytoestrogens | 📋 | | ⛔ | | 38140273 | Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density-A Systematic and Critical Review |
| Rosmarinic Acid | 📋 | ✍ | | | 36881913 | Proflactic effects of rosmarinic acid on spinal cord injury in rats |
| Salvianolic Acid | 📋 | | | | 37593175 | Salvianolic acid B attenuates inflammation and prevent pathologic fibrosis by inhibiting CD36-mediated activation of the PI3K-Akt signaling pathway in frozen shoulder |
| Silymarin | 📋 | ✍ | ⛔ | | 36087815 | Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model |
| Skullcap | 📋 | ✍ | ⛔ | | 38396803 | Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis |
| Vitamin A | 📋 | ✍ | ⛔ | | 38711977 | Vitamin A - discovery, metabolism, receptor signaling and effects on bone mass and fracture susceptibility |
| Aloe Vera | 📋 | ✍ | ⛔ | | 36243792 | Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis |
| Anethole | 📋 | | | | 37987213 | Anethole mitigates H2 O2 -induced inflammation in HIG-82 synoviocytes by suppressing the aquaporin 1 expression and activating the protein kinase A pathway |
| Arctiin | 📋 | | | | 37800616 | Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway |
| Astragalin | 📋 | | | | 36215870 | Astragalin mitigates inflammatory osteolysis by negatively modulating osteoclastogenesis via ROS and MAPK signaling pathway |
| Black Tea | 📋 | ✍ | ⛔ | | 33252307 | Black and Green Tea as Well as Specialty Teas Increase Osteoblast Mineralization with Varying Effectiveness |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 33519191 | Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review |
| Capsaicin | 📋 | ✍ | ⛔ | | 37120706 | Capsaicin Reduces Cancer Stemness and Inhibits Metastasis by Downregulating SOX2 and EZH2 in Osteosarcoma |
| Cordyceps | 📋 | ✍ | ⛔ | | 36500262 | Effect of Cordyceps spp. and Cordycepin on Functions of Bones and Teeth and Related Processes: A Review |
| Dioscin | 📋 | | | | 37055831 | Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study |
| Diosmetin | 📋 | | | | 36563736 | Diosmetin inhibits subchondral bone loss and indirectly protects cartilage in a surgically-induced osteoarthritis mouse model |
| Equol | 📋 | ✍ | ⛔ | | 37569440 | Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 37662796 | Efficacy of combination of N-acetylcysteine and primrose in spinal cord injury; an experimental study |
| Fenugreek | 📋 | ✍ | ⛔ | | 38098736 | The Healing Callus-Promoting Effect of Fenugreek in a Humerus Shaft Fracture: A Case Report |
| Ganoderic Acid | 📋 | | | | 37984927 | Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway |
| Ginger extract | 📋 | ✍ | ⛔ | | 36837393 | Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study |
| Gingerol | 📋 | ✍ | | | 33748100 | 10-Gingerol Suppresses Osteoclastogenesis in RAW264.7 Cells and Zebrafish Osteoporotic Scales |
| Glabridin | 📋 | | | | 37239211 | Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 35733771 | Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats |
| Hyperoside | 📋 | | | | 37157916 | Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis |
| Knotweed | 📋 | ✍ | ⛔ | | 37016525 | The possibility of Polygonum cuspidatum Against Osteoarthritis Based on Network Pharmacology and Molecular Docking |
| L-Carnosine | 📋 | ✍ | ⛔ | | 38003398 | Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38486093 | Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPKα lactylation in intervertebral disc degeneration |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38485925 | Moringa oleifera leaf extract promotes the healing of critical sized bone defects in the mandibles of rabbits |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38392200 | Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice |
| Olive Polyphenols | 📋 | | | | 33922438 | Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice |
| Pomegranate Seed extract | 📋 | | ⛔ | | 36193176 | Histological Evaluation of the Effect of Local Application of Punica granatum Seed Oil on Bone Healing |
| Prebiotics | 📋 | ✍ | ⛔ | | 37077156 | Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics |
| Saffron | 📋 | ✍ | ⛔ | | 37836391 | Crocus sativus L. Extract (Saffron) Effectively Reduces Arthritic and Inflammatory Parameters in Monotherapy and in Combination with Methotrexate in Adjuvant Arthritis |
| Schisandrins | 📋 | | | | 38422325 | Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway |
| Scutellarin | 📋 | | | | 36271561 | Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction |
| Shilajit | 📋 | ✍ | ⛔ | | 38073457 | Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury |
| Trehalose | 📋 | | ⛔ | | 37869632 | Trehalose delays postmenopausal osteoporosis by enhancing AKT/TFEB pathway‑dependent autophagy flow in rats |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38401303 | Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice |
| Walnut | 📋 | | ⛔ | | 35929358 | Evaluating the anti-arthritic potential of walnut (Juglans regia L.) in FCA induced Sprague Dawley rats |
| Acemannan | 📋 | | | | 33854714 | Acemannan-induced tooth socket healing: A 12-month randomized controlled trial |
| Antioxidants | 📋 | | ⛔ | | 38024517 | The reverse association of dietary antioxidant index with osteoporosis in postmenopausal iranian women: A case-control study |
| Apple Polyphenols | 📋 | | ⛔ | | 35788787 | Protective effects of apple polyphenols on bone loss in mice with high fat diet-induced obesity |
| Atractylodes | 📋 | ✍ | ⛔ | | 37268258 | Potential application of Atractylodes macrocephala Koidz. as a natural drug for bone mass regulation: A review |
| Biochanin A | 📋 | | | | 38227535 | Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation |
| Blackcurrant | 📋 | ✍ | ⛔ | | 36501004 | Blackcurrants Reduce the Risk of Postmenopausal Osteoporosis: A Pilot Double-Blind, Randomized, Placebo-Controlled Clinical Trial |
| Carnosol | 📋 | | | | 37415927 | Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells |
| Cat's Claw | 📋 | ✍ | ⛔ | | 26088322 | Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model |
| Catechins | 📋 | | | | 38259454 | J-shaped association of dietary catechins intake with the prevalence of osteoarthritis and moderating effect of physical activity: an American population-based cohort study |
| Cheese | 📋 | | ⛔ | | 38672942 | Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study |
| Cornus | 📋 | | | | 38111697 | Cornus officinalis: a potential herb for treatment of osteoporosis |
| Dandelion | 📋 | ✍ | ⛔ | | 30851708 | Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice |
| Diallyl Trisulfide | 📋 | | | | 38434350 | Diallyl trisulfide inhibits osteosarcoma 143B cell migration, invasion and EMT by inducing autophagy |
| Diosgenin | 📋 | | | | 37188832 | Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats |
| Emu Oil | 📋 | ✍ | ⛔ | | 28691132 | Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study) |
| Eucalyptol | 📋 | | | | 38649658 | Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2 |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 19941324 | Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 2: Rheumatoid arthritis |
| Glycine | 📋 | ✍ | ⛔ | | 37975960 | The Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury |
| Haritaki | 📋 | ✍ | ⛔ | | 36969583 | Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula |
| HMB | 📋 | ✍ | ⛔ | | 35010730 | Effects of β-Hydroxy β-Methylbutyric Supplementation in Combination with Conservative Non-Invasive Treatments in Athletes with Patellar Tendinopathy: A Pilot Study |
| Hops | 📋 | ✍ | ⛔ | | 37375599 | Effect of a Hop Extract Standardized in 8-Prenylnaringenin on Bone Health and Gut Microbiome in Postmenopausal Women with Osteopenia: A One-Year Randomized, Double-Blind, Placebo-Controlled Trial |
| Isoflavones | 📋 | ✍ | ⛔ | | 37875614 | Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38575308 | Lactobacillus plantarum 45 activates SHP2 through inhibition of oxidative stress to regulate osteoblast and osteoclast differentiation |
| Liquiritigenin | 📋 | | | | 37005251 | Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice |
| Liquiritin | 📋 | | | | 38423170 | Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis |
| Long Pepper | 📋 | | ⛔ | | 38670409 | Piper longum L. ameliorates gout through the MAPK/PI3K-AKT pathway |
| Maitake Mushrooms | 📋 | | ⛔ | | 33822504 | Medicinal Mushrooms for Prevention and Therapy of Osteoporosis (Review) |
| Mulberry | 📋 | | ⛔ | | 38309391 | Modulation of gut microbiota by crude mulberry polysaccharide attenuates knee osteoarthritis progression in rats |
| Myricetin | 📋 | | ⛔ | | 38164247 | Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model |
| Paeonol | 📋 | | | | 38394732 | MicroRNA let-7g links foam cell formation and adipogenic differentiation: A key regulator of Paeonol treating atherosclerosis-osteoporosis |
| Perilla | 📋 | ✍ | | | 36998613 | Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial |
| Persimmon | 📋 | | ⛔ | | 38674937 | Osteogenic Effects of the Diospyros lotus L. Leaf Extract on MC3T3-E1 Pre-Osteoblasts and Ovariectomized Mice via BMP2/4 and TGF β Pathways |
| Piperlongumine | 📋 | | | | 38334976 | Protective effects of piperlongumine against adjuvant-induced arthritis in rats through modulating OPG/RANKL/NF-κB signaling pathway |
| Protein | 📋 | ✍ | ⛔ | | 38220402 | Relationship of protein, calcium and vitamin D consumption with body composition and fractures in oldest-old independent people |
| PUFA | 📋 | | | | 36570136 | Causal effect of polyunsaturated fatty acids on bone mineral density and fracture |
| Quercitrin | 📋 | | | | 37952573 | Quercitrin attenuates the progression of osteoarthritis via inhibiting NF-κB signaling pathways and enhance glucose transport capacity |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 36031087 | Neuroprotective effects of lovastatin against traumatic spinal cord injury in rats |
| Rehmannia | 📋 | ✍ | ⛔ | | 37674829 | Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection |
| Rosemary | 📋 | ✍ | ⛔ | | 36142253 | Rosemary Extract-Induced Autophagy and Decrease in Accumulation of Collagen Type I in Osteogenesis Imperfecta Skin Fibroblasts |
| Sesame Oil | 📋 | | ⛔ | | 38172141 | Daily supplement of sesame oil prevents postmenopausal osteoporosis via maintaining serum estrogen and aromatase levels in rats |
| Shogaol | 📋 | | | | 36610124 | 6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway |
| Stigmasterol | 📋 | | | | 38064612 | Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats |
| Strawberry | 📋 | ✍ | ⛔ | | 38003966 | Amelioration of Rheumatoid Arthritis by Fragaria nubicola (Wild Strawberry) via Attenuation of Inflammatory Mediators in Sprague Dawley Rats |
| Taurine | 📋 | ✍ | ⛔ | | 36945935 | Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures |
| Vitamins | 📋 | | | | 38233761 | Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study |
| Wormwood | 📋 | ✍ | ⛔ | | 36335258 | Systems pharmacology approach to investigate the mechanism of Artemisia argyi in treating rheumatic diseases |
| Zingerone | 📋 | | | | 37724956 | Zingerone attenuates Ti particle-induced inflammatory osteolysis by suppressing the NF-κB signaling pathway in osteoclasts |
| Aged Garlic | 📋 | ✍ | ⛔ | | 27657047 | Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox1 |
| Aloe-Emodin | 📋 | | | | 28487948 | Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate |
| Anthocyanins | 📋 | ✍ | ⛔ | | 37796900 | Effectiveness of anthocyanin-rich foods on bone remodeling biomarkers of middle-aged and older adults at risk of osteoporosis: a systematic review, meta-analysis, and meta-regression |
| Barberry | 📋 | ✍ | ⛔ | | 36408260 | Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 35648689 | Protective Role of β-Sitosterol in Glucocorticoid-Induced Osteoporosis in Rats Via the RANKL/OPG Pathway |
| Black Pepper | 📋 | ✍ | ⛔ | | 34943090 | Herbal Preparation (Bromelain, Papain, Curcuma, Black Pepper) Enhances Mineralization and Reduces Glucocorticoid-Induced Osteoporosis in Zebrafish |
| Carotenoids | 📋 | ✍ | ⛔ | | 34878583 | Dietary carotenoid intake and osteoporosis: the National Health and Nutrition Examination Survey, 2005-2018 |
| Citicoline | 📋 | ✍ | ⛔ | | 28521906 | Spinal cord regeneration by modulating bone marrow with neurotransmitters and Citicholine: Analysis at micromolecular level |
| Cocoa | 📋 | ✍ | ⛔ | | 32953444 | Flavonoids from dark chocolate and (-)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 33850900 | Conjugated linoleic acid prompts bone formation in ovariectomized osteoporotic rats and weakens osteoclast formation after treatment with ultraviolet B |
| Costus | 📋 | ✍ | ⛔ | | 36451529 | Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen-induced arthritis in rats |
| Creatine | 📋 | ✍ | ⛔ | | 28901216 | Creatine or Vitamin D Supplementation in Individuals With a Spinal Cord Injury Undergoing Resistance Training: A Double-Blinded, Randomized Pilot Trial |
| Crocetin | 📋 | | | | 30618728 | In vivo and in vitro Approach to Anti-arthritic and Anti-inflammatory Effect of Crocetin by Alteration of Nuclear Factor-E2-Related Factor 2/hem Oxygenase (HO)-1 and NF-κB Expression |
| Cryptotanshinone | 📋 | | | | 36147634 | Radix Salvia miltiorrhiza for Ankylosing Spondylitis: Determining Potential Inflammatory Molecular Targets and Mechanism Using Network Pharmacology |
| Cyanidin | 📋 | ✍ | | | 35472676 | Cyanidin attenuates the high hydrostatic pressure-induced degradation of cellular matrix of nucleus pulposus cell via blocking the Wnt/β-catenin signaling |
| D-Mannose | 📋 | ✍ | ⛔ | | 38711073 | D-mannose alleviates intervertebral disc degeneration through glutamine metabolism |
| Fiber | 📋 | ✍ | ⛔ | | 38354209 | Association of dietary carbohydrate and fiber ratio with postmenopausal bone mineral density and prevalence of osteoporosis: A cross-sectional study |
| Fruits | 📋 | | | | 38672942 | Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 37918392 | Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1 |
| Geraniol | 📋 | | | | 37841186 | Geraniol Suppresses Oxidative Stress, Inflammation, and Interstitial Collagenase to Protect against Inflammatory Arthritis |
| Ginger Essential Oil | 📋 | ✍ | | | 31144450 | Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis |
| Glycyrrhetinic Acid | 📋 | | | | 38092318 | Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice |
| Grape | 📋 | | ⛔ | | 36878329 | Muscadine Grape (Vitis rotundifolia) and Wine Polyphenols Alleviated Arthritis and Restored the Gut Microbial Composition in Mice |
| Grapefruit | 📋 | | ⛔ | | 36839155 | Chondroprotective Effects of Grapefruit ( Citrus paradisi Macfad.) Juice in a Complete Freund's Adjuvant Rat Model of Knee Osteoarthritis |
| Guava | 📋 | | ⛔ | | 35818211 | The effect of Psidium guajava hydroalcoholic extract on reducing the expression of Resistin and TNF-α genes in articular chondrocytes of patients with knee osteoarthritis |
| Hawthorn | 📋 | ✍ | ⛔ | | 36071834 | Total flavonoids of hawthorn leaves protect spinal motor neurons via promotion of autophagy after spinal cord injury |
| Honey | 📋 | ✍ | ⛔ | | 36978815 | Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer |
| Honokiol | 📋 | | | | 36153410 | Sirt3 mediates the benefits of exercise on bone in aged mice |
| Icaritin | 📋 | | | | 38237539 | Metabolomics and pharmacodynamic analysis unveil the therapeutic role of icaritin on osteoporosis rats |
| Isoliquiritigenin | 📋 | | | | 38092318 | Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice |
| Isoquercitrin | 📋 | | | | 38065271 | Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway |
| L-Theanine | 📋 | ✍ | ⛔ | | 34531102 | Neuroprotective effect of l-theanine in a rat model of chronic constriction injury of sciatic nerve-induced neuropathic pain |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 33406724 | Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo |
| Linalool | 📋 | | ⛔ | | 37348232 | Linalool: Monoterpene alcohol effectiveness in chronic synovitis through lowering Interleukin-17, spleen and thymus indices |
| Loquat | 📋 | ✍ | ⛔ | | 31770567 | Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica |
| Lotus | 📋 | | ⛔ | | 38021731 | Nelumbo nucifera Leaf Extract Induces Cytotoxicity in Osteosarcoma Saos-2 Cells |
| Madecassoside | 📋 | | | | 33039960 | Regulation of gut microbiota substantially contributes to the induction of intestinal Treg cells and consequent anti-arthritis effect of madecassoside |
| Morin | 📋 | | | | 38093596 | Morin inhibits osteosarcoma migration and invasion by suppressing urokinase plasminogen activator through a signal transducer and an activator of transcription 3 |
| Morusin | 📋 | | | | 37807416 | Morusin Inhibits RANKL-induced Osteoclastogenesis and Ovariectomized Osteoporosis |
| Myrrh | 📋 | ✍ | ⛔ | | 35565111 | Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients |
| Orange | 📋 | | ⛔ | | 20707201 | [Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis] |
| Pineapple | 📋 | ✍ | ⛔ | | 27181794 | Anti-rheumatic activity of Ananas comosus fruit peel extract in a complete Freund's adjuvant rat model |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 37640280 | An aqueous extract of Prunella vulgaris L. ameliorates cadmium-induced bone loss by promoting osteogenic differentiation in female rats |
| Rapamycin | 📋 | ✍ | | | 37393367 | Rapamycin prevents lung injury related to acute spinal cord injury in rats |
| Raspberry | 📋 | ✍ | ⛔ | | 35799169 | Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial |
| Retinoic Acid | 📋 | | | | 38245637 | All-trans retinoic acid alleviates collagen-induced arthritis and promotes intestinal homeostasis |
| Rosavin | 📋 | | ⛔ | | 38396794 | The Role of Rosavin in the Pathophysiology of Bone Metabolism |
| Rosehip | 📋 | ✍ | ⛔ | | 34348637 | Anti-inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules |
| Safranal | 📋 | | | | 37004404 | Safranal inhibits estrogen-deficiency osteoporosis by targeting Sirt1 to interfere with NF-κB acetylation |
| Sage | 📋 | ✍ | ⛔ | | 35015090 | New bone-generative effect of Salvia officinalis L. in the expanded midpalatal suture : An in vivo and in vitro study |
| Sesame | 📋 | ✍ | ⛔ | | 37212033 | A comprehensive review of the bioactive components of sesame seeds and their impact on bone health issues in postmenopausal women |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 33822504 | Medicinal Mushrooms for Prevention and Therapy of Osteoporosis (Review) |
| Spermidine | 📋 | | | | 38367900 | Spermidine ameliorates osteoarthritis via altering macrophage polarization |
| Spikenard | 📋 | ✍ | ⛔ | | 35962465 | Nardosinone suppresses monoiodoacetate-induced osteoarthritis in rats: The key role of the miR-218-5p/NUMB axis |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 27209059 | Does stinging nettle (Urtica dioica) have an effect on bone formation in the expanded inter-premaxillary suture? |
| Syringic Acid | 📋 | | | | 38616762 | Syringic Acid Attenuates the IL-1β-Induced Akt Pathway in Chondrocyte ATDC5 Cells |
| Tamarind | 📋 | | ⛔ | | 37351019 | Efficacy of a proprietary combination of Tamarindus indica seeds and Curcuma longa rhizome extracts in osteoarthritis: a clinical investigation |
| Tangeretin | 📋 | | | | 35104760 | Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways |
| Terpenoids | 📋 | | | | 35651977 | Evolving Roles of Natural Terpenoids From Traditional Chinese Medicine in the Treatment of Osteoporosis |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 30888914 | Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca 2+-Sparing Effect |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 37788723 | Riboflavin deficiency reduces bone mineral density in rats by compromising osteoblast function |
| Whey Protein | 📋 | ✍ | ⛔ | | 37447191 | Whey Protein Hydrolysate Ameliorated High-Fat-Diet Induced Bone Loss via Suppressing Oxidative Stress and Regulating GSK-3β/Nrf2 Signaling Pathway |
| Withanolides | 📋 | | | | 34925020 | Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 36766210 | α-Linolenic Acid Inhibits RANKL-Induced Osteoclastogenesis In Vitro and Prevents Inflammation In Vivo |
| Argan Oil | 📋 | ✍ | ⛔ | | 28699499 | Effectiveness of Argan Oil Consumption on Knee Osteoarthritis Symptoms: A Randomized Controlled Clinical Trial |
| Arjuna | 📋 | ✍ | ⛔ | | 34798688 | Anti-osteoporotic effect of Terminalia arjuna (Roxb.) Wight & Arn. In bilateral ovariectomized induced post-menopausal osteoporosis in experimental rats |
| Balloon Flower | 📋 | ✍ | ⛔ | | 38312605 | A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways |
| Bergamot | 📋 | ✍ | ⛔ | | 37748407 | Bergapten exerts a chondroprotective effect in temporomandibular joint osteoarthritis by combining intestinal flora alteration and reactive oxygen species reduction |
| Betulinic Acid | 📋 | | | | 37789884 | Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1 β Maturation and Secretion |
| Burdock | 📋 | | ⛔ | | 28801728 | Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model |
| Butyrate | 📋 | | ⛔ | | 37619784 | Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway |
| Caffeine | 📋 | ✍ | ⛔ | | 34363706 | Habitual caffeine intake affects implant osseointegration: An in vivo study |
| Chamomile | 📋 | ✍ | ⛔ | | 35883807 | Prophylactic Anti-Osteoporotic Effect of Matricaria chamomilla L. Flower Using Steroid-Induced Osteoporosis in Rat Model and Molecular Modelling Approaches |
| Cinnamic Acid | 📋 | | | | 35799788 | A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis |
| Coconut Oil | 📋 | | ⛔ | | 36140928 | Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice |
| Cordycepin | 📋 | | | | 36500262 | Effect of Cordyceps spp. and Cordycepin on Functions of Bones and Teeth and Related Processes: A Review |
| Coriander | 📋 | | ⛔ | | 36082821 | Anti‑osteoclastogenic effects of Coriandrum sativum L. via the NF‑κB and ERK‑mediated NFATc1 signaling pathways |
| Cranberry | 📋 | ✍ | ⛔ | | 33636418 | Beneficial effects of fish oil and cranberry juice on disease activity and inflammatory biomarkers in people with rheumatoid arthritis |
| Cucumber | 📋 | | ⛔ | | 36748212 | Standardised ido-BR1 Cucumber Extract Improved Parameters Linked to Moderate Osteoarthritis in a Placebo-controlled Study |
| Diallyl Sulfide | 📋 | | | | 33556823 | Allyl sulfide promotes osteoblast differentiation and bone density via reducing mitochondrial DNA release mediated Kdm6b/H3K27me3 epigenetic mechanism |
| Egg | 📋 | | ⛔ | | 38696440 | Egg consumption and bone mass density among the elderly: A scoping review |
| Fennel | 📋 | ✍ | ⛔ | | 32835919 | Effect of sweet fennel seed extract capsule on knee pain in women with knee osteoarthritis |
| Fish | 📋 | | ⛔ | | 35907830 | The relationship between animal flesh foods consumption and rheumatoid arthritis: a case-control study |
| Gardenia | 📋 | | ⛔ | | 37474993 | [Mechanism of Gardeniae Fructus in ameliorating rheumatoid arthritis based on metabolomics and intestinal microbiota] |
| Genipin | 📋 | | | | 37157220 | Genipin inhibits the development of osteosarcoma through PI3K/AKT signaling pathway |
| Geraniin | 📋 | | | | 33755276 | Antiosteoporosis effect of geraniin on ovariectomy-induced osteoporosis in experimental rats |
| Ginkgetin | 📋 | | | | 37154418 | Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome |
| Hemp Oil | 📋 | ✍ | ⛔ | | 36837393 | Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study |
| Inulin | 📋 | ✍ | ⛔ | | 34200082 | Prebiotic Food Intake May Improve Bone Resorption in Japanese Female Athletes: A Pilot Study |
| Jasmine | 📋 | | ⛔ | | 34119929 | Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models |
| L-Lysine | 📋 | ✍ | ⛔ | | 33290094 | Protein, lysine and vitamin D: critical role in muscle and bone health |
| Lecithin | 📋 | ✍ | ⛔ | | 34603603 | Combined effects of soy isoflavone and lecithin on bone loss in ovariectomized mice |
| Lemon Verbena | 📋 | | ⛔ | | 22087615 | A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management |
| Limonin | 📋 | | | | 36856818 | Limonin delays the progression of intervertebral disc degeneration in vivo and in vitro: the key role of the MAPK/NF-κB and necroptosis pathways |
| Lutein | 📋 | ✍ | ⛔ | | 31168346 | Protective Effect of Lutein on Spinal Cord Ischemia-Reperfusion Injury in Rats |
| Mango Leaf | 📋 | | ⛔ | | 26229343 | Antiarthritic activity of a polyherbal formulation against Freund's complete adjuvant induced arthritis in Female Wistar rats |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 36343609 | Locally delivered modified citrus pectin - a galectin-3 inhibitor shows expected anti-inflammatory and unexpected regeneration-promoting effects on repair of articular cartilage defect |
| Neem | 📋 | ✍ | | | 37450077 | Nimbin (N1) and analog N3 from the neem seeds suppress the migration of osteosarcoma MG-63 cells and arrest the cells in a quiescent state mediated via activation of the caspase-modulated apoptotic pathway |
| Nuts | 📋 | | ⛔ | | 37950985 | Higher lacto-vegetarian dietary score is associated with reduced risk of postmenopausal osteoporosis: A case-control study in a sample of Iranian postmenopausal women |
| Oleanolic Acid | 📋 | | | | 38471277 | Oleanolic acid exerts bone anabolic effects via activation of osteoblastic 25-hydroxyvitamin D 1-alpha hydroxylase |
| Papain | 📋 | ✍ | ⛔ | | 34943090 | Herbal Preparation (Bromelain, Papain, Curcuma, Black Pepper) Enhances Mineralization and Reduces Glucocorticoid-Induced Osteoporosis in Zebrafish |
| Patchouli | 📋 | ✍ | ⛔ | | 35720186 | Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 29317792 | Tabetri™ ( Tabebuia avellanedae Ethanol Extract) Ameliorates Osteoarthritis Symptoms Induced by Monoiodoacetate through Its Anti-Inflammatory and Chondroprotective Activities |
| PEA | 📋 | ✍ | ⛔ | | 35565111 | Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients |
| Potassium | 📋 | ✍ | ⛔ | | 37875826 | Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES) |
| Pregnenolone | 📋 | ✍ | ⛔ | | 32292342 | Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss |
| Proanthocyanidins | 📋 | | | | 37715945 | Proanthocyanidin enhances the endogenous regeneration of alveolar bone by elevating the autophagy of PDLSCs |
| Progesterone | 📋 | ✍ | ⛔ | | 36273543 | Molecular docking and molecular dynamics simulation studies the mechanism of progesterone in the treatment of spinal cord injury |
| Rhodiola | 📋 | ✍ | ⛔ | | 38156377 | Mechanism of Rhodiola rosea-Euonymus alatus drug pair against rheumatoid arthritis: Network pharmacology and experimental validation |
| Royal Jelly | 📋 | ✍ | ⛔ | | 36724964 | Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly |
| Scutellarein | 📋 | | | | 38695125 | Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies |
| Sesamol | 📋 | | | | 37778247 | Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids |
| Shea | 📋 | | ⛔ | | 32099450 | Vitellaria paradoxa Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats |
| Sirtuin Activators | 📋 | | | | 38264287 | Sirtuins mediate mitochondrial quality control mechanisms: a novel therapeutic target for osteoporosis |
| Stevia | 📋 | ✍ | ⛔ | | 36630751 | Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37887397 | The Impact of Tannic Acid Consumption on Bone Mineralization |
| Tea Polyphenols | 📋 | | | | 38307369 | Study on the relationship between tea polyphenols alleviating osteoporosis and the changes of microorganism-metabolite-intestinal barrier |
| Telmisartan | 📋 | | ⛔ | | 35384052 | Telmisartan: An angiotensin receptor blocker regulates osteoclastogenesis via inhibition of the ERK triggering in osteoporotic male rats |
| Theobromine | 📋 | ✍ | ⛔ | | 32146317 | Theobromine mitigates IL-1β-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes |
| Thyme | 📋 | ✍ | ⛔ | | 31124455 | Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis |
| Toothache Plant | 📋 | | | | 33973686 | Acmella oleracea extract increases collagen content and organization in partially transected tendons |
| Vegetables | 📋 | | | | 37950985 | Higher lacto-vegetarian dietary score is associated with reduced risk of postmenopausal osteoporosis: A case-control study in a sample of Iranian postmenopausal women |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 38180674 | Association between niacin intake and knee osteoarthritis pain and function: a longitudinal cohort study |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 31497217 | Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation |
| Vitexin | 📋 | | | | 36538589 | Vitexin Regulates Angiogenesis and Osteogenesis in Ovariectomy-Induced Osteoporosis of Rats via the VDR/PI3K/AKT/eNOS Signaling Pathway |
| Yogurt | 📋 | | ⛔ | | 37706070 | Dairy intake and risk of hip fracture in prospective cohort studies: non-linear algorithmic dose-response analysis in 486 950 adults |
| 5-HTP | 📋 | ✍ | ⛔ | | 26669765 | Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis |
| Alfalfa | 📋 | | ⛔ | | 32193946 | Effect of Medicago sativa compared To 17β-oestradiol on osteoporosis in ovariectomized mice |
| Almond | 📋 | | ⛔ | | 34098995 | The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit |
| Alpha GPC | 📋 | ✍ | ⛔ | | 29191088 | The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice |
| Amaranth | 📋 | | ⛔ | | 32529499 | Dietary amaranths modulate the immune response via balancing Th1/Th2 and Th17/Treg response in collagen-induced arthritis |
| Amino Acids | 📋 | | | | 36079884 | Effects of Non-Essential Amino Acids on Knee Joint Conditions in Adults: A Randomised, Double-Blind, Placebo-Controlled Trial |
| Anise | 📋 | ✍ | ⛔ | | 15537303 | Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties |
| Anthocyanidins | 📋 | | | | 37656219 | Associations of Dietary Anthocyanidins Intake with Bone Health in Children: A Cross-Sectional Study |
| Apple | 📋 | | ⛔ | | 25271471 | Consumption of dried apple peel powder increases joint function and range of motion |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 32813003 | The opposite effects of Antarctic krill oil and arachidonic acid-rich oil on bone resorption in ovariectomized mice |
| Arnica | 📋 | ✍ | ⛔ | | 25966322 | Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress |
| Azadirachtin | 📋 | | | | 31225646 | Estrogen receptor activation in response to Azadirachtin A stimulates osteoblast differentiation and bone formation in mice |
| Banana | 📋 | | ⛔ | | 34662767 | Extract and fraction of Musa paradisiaca flower have osteogenic effect and prevent ovariectomy induced osteopenia |
| Basil | 📋 | ✍ | ⛔ | | 27255519 | Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 27446227 | Essential Oil of Ocimum basilicum L. and (-)-Linalool Blocks the Excitability of Rat Sciatic Nerve |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 27840967 | Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice |
| Bergamottin | 📋 | | | | 35188515 | Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt/β-catenin signaling pathway |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 33915775 | Biological Effects of β-Glucans on Osteoclastogenesis |
| Betaine | 📋 | ✍ | ⛔ | | 34658862 | Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone |
| Bilobalide | 📋 | | | | 36337189 | Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities |
| Bitter Melon | 📋 | ✍ | ⛔ | | 37586334 | Momordica charantia enhances tendon healing in rats: An experimental study |
| Black Ginger | 📋 | ✍ | ⛔ | | 33799537 | Kaempferia parviflora Extract Alleviated Rat Arthritis, Exerted Chondroprotective Properties In Vitro, and Reduced Expression of Genes Associated with Inflammatory Arthritis |
| Brazil Nut | 📋 | | ⛔ | | 35762459 | Supplementation of diet with Brazil nut modulates body composition, bone parameters, and lipid peroxidation in Wistar rats |
| Bread | 📋 | | | | 36130461 | Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative |
| Broccoli | 📋 | | ⛔ | | 34704882 | Bioactive compounds and therapeutic role of Brassica oleracea L. seeds in rheumatoid arthritis rats via regulating inflammatory signaling pathways and antagonizing interleukin-1 receptor action |
| Buckwheat | 📋 | | ⛔ | | 23675837 | Anti-arthritic activity of ethanol extract of Fagopyrum cymosum with adjuvant-induced arthritis in rats |
| Cabbage | 📋 | | ⛔ | | 35719197 | Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial |
| Camellia | 📋 | | ⛔ | | 19230411 | [Study on the theraputic effect of plants of Camellia genus on osteoporosis] |
| Camphor | 📋 | ✍ | ⛔ | | 20353012 | [Study on antiinflammatory effect of different chemotype of Cinnamomum camphora on rat arthritis model induced by Freund's adjuvant] |
| Castor Oil | 📋 | ✍ | ⛔ | | 34712426 | Anti-arthritic activity of Ricinus communis L. and Withania somnifera L. extracts in adjuvant-induced arthritic rats via modulating inflammatory mediators and subsiding oxidative stress |
| Catalase | 📋 | ✍ | ⛔ | | 37879214 | Combination of curcumin and catalase protects against chondrocyte injury and knee osteoarthritis progression by suppressing oxidative stress |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 32334386 | α-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis |
| Chebulinic Acid | 📋 | | | | 36423891 | Chebulinic acid alleviates LPS-induced inflammatory bone loss by targeting the crosstalk between reactive oxygen species/NFκB signaling in osteoblast cells |
| Chicoric Acid | 📋 | | | | 35961266 | Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model |
| Chicory | 📋 | ✍ | ⛔ | | 27255519 | Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats |
| Chitosan | 📋 | ✍ | ⛔ | | 33291821 | Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model |
| Choline | 📋 | ✍ | ⛔ | | 34076003 | Low dietary choline intake is associated with the risk of osteoporosis in elderly individuals: a population-based study |
| Chromium | 📋 | ✍ | ⛔ | | 38474436 | Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats |
| Citronella Essential Oil | 📋 | ✍ | ⛔ | | 38498112 | Potential anti-gouty arthritis of Citronella essential oil and Nutmeg essential oil through reducing oxidative stress and inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 26045743 | Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model |
| Clove | 📋 | | ⛔ | | 21711176 | Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy |
| Colostrum | 📋 | ✍ | ⛔ | | 38474792 | Effects of Dietary Colostrum Basic Protein on Bone Growth and Calcium Absorption in Mice |
| Coptis Chinensis | 📋 | | ⛔ | | 37637408 | Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms |
| Corn | 📋 | | ⛔ | | 33479339 | Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-κB and MAPK signaling |
| Corn Silk | 📋 | ✍ | ⛔ | | 36276864 | Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis |
| Coumaric acid | 📋 | | | | 37139674 | P-coumaric acid inhibits osteosarcoma growth by inhibiting PI3K / Akt signaling pathway |
| Cumin | 📋 | | ⛔ | | 38125945 | Assessment of anticancer properties of cumin seed ( Cuminum cyminum) against bone cancer |
| D-Limonene | 📋 | ✍ | ⛔ | | 37189712 | In Vitro Screening Studies on Eight Commercial Essential Oils-Derived Compounds to Identify Promising Natural Agents for the Prevention of Osteoporosis |
| Delphinidin | 📋 | | | | 32155282 | The dietary anthocyanin delphinidin prevents bone resorption by inhibiting Rankl-induced differentiation of osteoclasts in a medaka (Oryzias latipes) model of osteoporosis |
| Dill | 📋 | | ⛔ | | 37836586 | Anti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds |
| DIM | 📋 | ✍ | ⛔ | | 36438802 | 3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy |
| Echinacea | 📋 | ✍ | ⛔ | | 27737573 | The Effect and Safety of Highly Standardized Ginger (Zingiber Officinale) and Echinacea (Echinacea Angustifolia) Extract Supplementation on Inflammation and Chronic Pain in NSAIDs Poor Responders. A Pilot Study in Subjects With Knee Arthrosis |
| Elderberry | 📋 | ✍ | ⛔ | | 30186170 | A Metabolomics Study on the Bone Protective Effects of a Lignan-Rich Fraction From Sambucus Williamsii Ramulus in Aged Rats |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 36232583 | Role of Essential Amino Acids in Age-Induced Bone Loss |
| Eucalyptus | 📋 | ✍ | ⛔ | | 36060153 | The effect of eucalyptus inhalation on pain and the quality of life in rheumatoid arthritis |
| Flaxseed | 📋 | ✍ | ⛔ | | 34837524 | The effect of flaxseed with or without anti-inflammatory diet in patients with rheumatoid arthritis, a randomized controlled trial |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 35099432 | Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis |
| Forskolin | 📋 | ✍ | ⛔ | | 36926021 | A standardized extract of Coleus forskohlii root protects rats from ovariectomy-induced loss of bone mass and strength, and impaired bone material by osteogenic and anti-resorptive mechanisms |
| GABA | 📋 | ✍ | ⛔ | | 38084676 | Gamma-aminobutyric acid (GABA)-mediated bone formation and its implications for anti-osteoporosis strategies: Exploring the relation between GABA and GABA receptors |
| Geranium | 📋 | | | | 35832768 | Geranium wallichianum D. Don Ex Sweet Ameliorates Rheumatoid Arthritis by Curtailing the Expression of COX-II and Inflammatory Cytokines as Well as by Alleviating the Oxidative Stress |
| Giloy | 📋 | ✍ | ⛔ | | 36840884 | In vitro and in vivo anti-inflammatory and anti-arthritic effect of Tinospora cordifolia via modulation of JAK/STAT pathway |
| Glutathione | 📋 | ✍ | ⛔ | | 33717929 | The protective role of glutathione in osteoarthritis |
| Grape Seed Oil | 📋 | | ⛔ | | 32912277 | The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Graviola | 📋 | ✍ | ⛔ | | 35485570 | Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis |
| Guggul | 📋 | ✍ | ⛔ | | 27548493 | Effects of Balsamodendron mukul Gum Resin Extract on Articular Cartilage in Papain-induced Osteoarthritis |
| Guggulsterone | 📋 | | | | 30905781 | Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling |
| Holy Basil | 📋 | ✍ | ⛔ | | 18762236 | Ameliorative Effects of Ocimum Sanctum in Sciatic Nerve Transection-Induced Neuropathy in Rats |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 38574619 | Equisetum arvense standardized dried extract hinders age-related osteosarcopenia |
| Isorhamnetin | 📋 | | | | 38212502 | Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway |
| Jujube | 📋 | | ⛔ | | 36896317 | Effects of Ziziphus Jujuba Extract Alone and Combined with Boswellia Serrata Extract on Monosodium Iodoacetate Model of Osteoarthritis in Mice |
| Kiwifruit | 📋 | ✍ | ⛔ | | 29387722 | A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats |
| L-Citrulline | 📋 | ✍ | ⛔ | | 38679918 | Mass Spectrometry Reveals Molecular Effects of Citrulline Supplementation during Bone Fracture Healing in a Rat Model |
| L-Proline | 📋 | ✍ | ⛔ | | 15729747 | Reduction in Tibial Shaft Fracture Healing Time With Essential Nutrient Supplementation Containing Ascorbic Acid, Lysine, and Proline |
| Lauric Acid | 📋 | ✍ | | | 33359913 | Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 27863613 | Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial |
| Lemon Balm | 📋 | ✍ | ⛔ | | 34201872 | The Stimulating Effect of Rosmarinic Acid and Extracts from Rosemary and Lemon Balm on Collagen Type I Biosynthesis in Osteogenesis Imperfecta Type I Skin Fibroblasts |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 35807786 | Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis |
| Lupeol | 📋 | | | | 35446470 | Protective effect of lupeol on arthritis induced by type II collagen via the suppression of P13K/AKT signaling pathway in Sprague dawley rats |
| Maca Root | 📋 | ✍ | ⛔ | | 16466876 | Effect of ethanol extract of Lepidium meyenii Walp. on osteoporosis in ovariectomized rat |
| Magnolia | 📋 | ✍ | ⛔ | | 33990219 | Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways |
| Magnolol | 📋 | | | | 36039427 | Magnolol Suppresses ERK/NF-κB Signaling and Triggers Apoptosis Through Extrinsic/Intrinsic Pathways in Osteosarcoma |
| Mandarin | 📋 | | | | 33105861 | Efficacy and Safety of Kudzu Flower-Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial |
| Manganese | 📋 | ✍ | ⛔ | | 33575164 | Overview of methods for enhancing bone regeneration in distraction osteogenesis: Potential roles of biometals |
| Mango | 📋 | | ⛔ | | 35662629 | Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio |
| Mastic | 📋 | ✍ | ⛔ | | 34378260 | Effectiveness of Pistacia atlantica on older adult knee osteoarthritis, a randomized triple blind clinical trial |
| Minerals | 📋 | | | | 35004740 | The Impact of Trace Elements on Osteoarthritis |
| Mint | 📋 | | ⛔ | | 34421614 | Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation |
| Neferine | 📋 | | | | 31127627 | Neferine suppresses osteoclast differentiation through suppressing NF-κB signal pathway but not MAPKs and promote osteogenesis |
| Nicotinamide | 📋 | ✍ | ⛔ | | 34282229 | Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis |
| Noni | 📋 | | ⛔ | | 34359507 | MicroRNAs Involved in the Therapeutic Functions of Noni ( Morinda citrifolia L.) Fruit Juice in the Treatment of Acute Gouty Arthritis in Mice Induced with Monosodium Urate |
| Nootkatone | 📋 | | | | 34492535 | Nootkatone protects cartilage against degeneration in mice by inhibiting NF-κB signaling pathway |
| Nuciferine | 📋 | | | | 38658097 | Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance |
| Nutmeg Essential Oil | 📋 | | ⛔ | | 38498112 | Potential anti-gouty arthritis of Citronella essential oil and Nutmeg essential oil through reducing oxidative stress and inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity |
| Omega-9 Fatty Acids | 📋 | | | | 35956341 | Omega-9 Modifies Viscoelasticity and Augments Bone Strength and Architecture in a High-Fat Diet-Fed Murine Model |
| Oolong Tea | 📋 | | ⛔ | | 32189157 | Oolong tea drinking boosts calcaneus bone mineral density in postmenopausal women: a population-based study in southern China |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Oregano | 📋 | ✍ | ⛔ | | 35024741 | Evaluation of cytotoxic activity and anticancer potential of indigenous Rosemary (Rosmarinus officinalis L.) and Oregano (Origanum vulgare L.) dry extracts on MG-63 bone osteosarcoma human cell line |
| Osmanthus | 📋 | ✍ | ⛔ | | 36678965 | The Ethanol Extracts of Osmanthus fragrans Leaves Ameliorate the Bone Loss via the Inhibition of Osteoclastogenesis in Osteoporosis |
| Oyster | 📋 | | ⛔ | | 35267311 | Fermented Oyster ( Crassostrea gigas) Extract Cures and Prevents Prednisolone-Induced Bone Resorption by Activating Osteoblast Differentiation |
| Oyster Mushrooms | 📋 | | ⛔ | | 33822504 | Medicinal Mushrooms for Prevention and Therapy of Osteoporosis (Review) |
| Parsley | 📋 | | ⛔ | | 27255519 | Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats |
| Pelargonidin | 📋 | | | | 37315775 | Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway |
| Phloretin | 📋 | | | | 34836440 | Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 21194249 | Efficacy and Safety of Meriva®, a Curcumin-Phosphatidylcholine Complex, During Extended Administration in Osteoarthritis Patients |
| Phytosterols | 📋 | | | | 37756430 | Phytosterols Protect against Osteoporosis by Regulating Gut Microbiota |
| Pine Nut | 📋 | | ⛔ | | 34080609 | Anti-inflammatory and immunoregulatory effects of pinolenic acid in rheumatoid arthritis |
| Potato | 📋 | | ⛔ | | 35223568 | The Relationship between Dietary Patterns and Bone Mineral Density of 476 Middle-Aged and Aged People |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 28620304 | Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro |
| Pygeum Africanum | 📋 | ✍ | ⛔ | | 35487926 | GC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark |
| Quinoa | 📋 | | ⛔ | | 38284744 | Quinoa alleviates osteoporosis in ovariectomized rats by regulating gut microbiota imbalance |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 31144450 | Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis |
| Safflower | 📋 | ✍ | ⛔ | | 16883631 | Effects of Safflower seed oil in osteoporosis induced-ovariectomized rats |
| Salt | 📋 | | ⛔ | | 36028560 | The association between dietary sodium intake and osteoporosis |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 36079860 | Anti-Osteoporosis Effects of the Fruit of Sea Buckthorn ( Hippophae rhamnoides) through Promotion of Osteogenic Differentiation in Ovariectomized Mice |
| Sea Cucumber | 📋 | | | | 32467988 | Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
| Seafood | 📋 | | | | 35907830 | The relationship between animal flesh foods consumption and rheumatoid arthritis: a case-control study |
| Seaweeds | 📋 | | ⛔ | | 35287916 | Role of sulfated polysaccharides from seaweeds in bone regeneration: A systematic review |
| Sesamolin | 📋 | | | | 34194327 | Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways |
| Silica | 📋 | ✍ | ⛔ | | 33715532 | Silicon: A neglected micronutrient essential for bone health |
| Soy Protein | 📋 | ✍ | ⛔ | | 37950985 | Higher lacto-vegetarian dietary score is associated with reduced risk of postmenopausal osteoporosis: A case-control study in a sample of Iranian postmenopausal women |
| Spearmint | 📋 | | ⛔ | | 25058311 | High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 28107842 | Mentha spicata as natural analgesia for treatment of pain in osteoarthritis patients |
| Spices | 📋 | | | | 33322318 | Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 33063931 | Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway |
| St. Johns Wort Oil | 📋 | | ⛔ | | 38242739 | The Effect of St. John's Wort Oil (Hypericum Perforatum L.) in Knee Osteoarthritis: A Randomized Controlled and Qualitative Study |
| Star Anise | 📋 | ✍ | ⛔ | | 37971467 | Protective Effect of Illicium Verum Extract On Vascularization In Rats With Osteoporotic Fracture |
| Sulfur | 📋 | ✍ | ⛔ | | 36187121 | Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules |
| Sweet Potato | 📋 | | ⛔ | | 37953101 | Purple sweet potato (Ipomoea batatas L.) extract effects on levels of inflammatory markers and chondrocyte count in gout arthritis Wistar rat model |
| Tetrahydrocurcumin | 📋 | ✍ | | | 27482294 | Curcumin and Tetrahydrocurcumin Both Prevent Osteoarthritis Symptoms and Decrease the Expressions of Pro-Inflammatory Cytokines in Estrogen-Deficient Rats |
| Theabrownins | 📋 | | | | 30119205 | Theabrownin suppresses in vitro osteoclastogenesis and prevents bone loss in ovariectomized rats |
| Thymol | 📋 | ✍ | ⛔ | | 30048646 | Thymol inhibits RANKL-induced osteoclastogenesis in RAW264.7 and BMM cells and LPS-induced bone loss in mice |
| Trans-Resveratrol | 📋 | | | | 15857203 | Effects of Trans-Resveratrol From Polygonum Cuspidatum on Bone Loss Using the Ovariectomized Rat Model |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 27649725 | Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation |
| UDCA | 📋 | ✍ | ⛔ | | 38313166 | Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis |
| Valerian Root | 📋 | ✍ | ⛔ | | 34874327 | The effect of Iridoids effective fraction of Valeriana jatamansi Jones on movement function in rats after acute cord injury and the related mechanism |
| Vitamin B Complex | 📋 | | ⛔ | | 34610784 | Adequate intake and supplementation of B vitamins, in particular folic acid, can play a protective role in bone health |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 15729747 | Reduction in Tibial Shaft Fracture Healing Time With Essential Nutrient Supplementation Containing Ascorbic Acid, Lysine, and Proline |
| Vitex | 📋 | ✍ | ⛔ | | 36121091 | Potential Phytoconstituents of Genus Vitex for the Management of Rheumatoid Arthritis: A Review |
| White Mushrooms | 📋 | | ⛔ | | 33635072 | Agaricus bisporus-Derived Glucosamine Hydrochloride Facilitates Skeletal Injury Repair through Bmp Signaling in Zebrafish Osteoporosis Model |
| White Tea | 📋 | | ⛔ | | 33252307 | Black and Green Tea as Well as Specialty Teas Increase Osteoblast Mineralization with Varying Effectiveness |
| Wine | 📋 | | ⛔ | | 36238230 | Beer, wine, and spirits differentially influence body composition in older white adults-a United Kingdom Biobank study |
| Yam | 📋 | | | | 34721647 | Total Saponin of Dioscorea collettii Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Activation of the TLR4/NF- κ B Signaling Pathway |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 28880221 | The Macular Carotenoids Lutein and Zeaxanthin Are Related to Increased Bone Density in Young Healthy Adults |
